Prof. Frank Grosveld is involved in the study of temporal and spatial
aspects of globin gene regulation. His group was the first to characterise and study
a human Locus Control Region and also generated a number of useful knockout-mouse
lines. He is actively involved in the study of the molecular mechanisms which govern
the transcriptional silencing of the human γ-globin genes. Finally, he is involved
in the generation of α and β-globin locus microarrays for high-throughput
diagnostics. Such microarrays can be employed in the characterisation of known and
unknown deletions, responsible for α- and β-thalassaemia.